Epigenetic changes such as DNA methylation and histone modification play a role in carcinogenesis. In a recent research the overall level of histone modifications were compared between malignant and normal prostate epithelial cells.
Methylation of H3K9 and acetylation of H3 and H4 were found do be significantly reduced in the malignant cells. It was found out that two specific modifications can distinguish normal from cancer cells with high sensitivity and specificity.
this paper supports the formerly established concept that epigenetics plays a major role in cancer. Cancer is considered to be a genetic disease but there are cases in which the epigenetic code is changed while the genetic code is not altered.
The research was headed by Jörg Ellinger from the University of Bonn, Germany and was published in the Prostate on Sep-2009.
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